Review: antiemetic drugs reduce nausea in early pregnancy.

Main results 23 trials were included. Antiemetic medication reduced nausea more than did placebo (12 RCTs) but caused more drowsiness and sleepiness (4 RCTs) (table). 3 trials compared Bendectin with placebo and showed a reduction in nausea similar to that with all antiemetics combined (odds ratio [OR] 0.28, 95% CI 0.16 to 0.51). 2 trials showed no effect of vitamin B-6 on vomiting (OR 0.91, CI 0.60 to 1.38). Pericardium 6 (p6) acupressure reduced morning sickness more than did placebo or dummy acupressure (2 RCTs) (OR 0.35, CI 0.23 to 0.54), although 1 trial that could not be combined in the metaanalysis because of randomisation concerns showed no benefit. 5 trials examined hyperemesis gravidarum, and none of the interventions (adrenocorticotrophic hormone, diazepam, methylprednisolone, and ondansetron) showed a reduction in vomiting. These interventions did not show benefit for reducing hospital admissions; however, methylprednisolone or diazepam reduced the rate of readmission, and diazepam reduced the length of hospital stay.